klothoskin.com Reviews 

4
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TrustScore 4 out of 5

4.0

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4.0

Great

TrustScore 4 out of 5

4 reviews

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4.0

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(4)

3 reviews in the last 12 months

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Rated 5 out of 5 stars

Klotho creams made a difference to my…

Klotho creams made a difference to my skin in about a month. I noticed brighter complexion, and smoother skin. Small wrinkles because flatter and less noticeable. It’s not a cheap product, but it works. And I got compliments from people who see me regularly. So, I recommend it.

1 May 2026
Unprompted review
Rated 5 out of 5 stars

3 DECADES OF SAVING MY FACE!!!!!

I first went to Dr Gail Humble 30+ years ago because she was one of a handful of doctors refining and teaching newer technology...like Thread Lifts (magical) So when she felt KLOTHO SKIN was scientifically ready to share with the public I was eager and REMAIN dedicated to the EYE SERUM and...OMG that NIGHT CREAM. Yes it is a splurge. A big one for someone like me. BUT WORTH IT. And the customer service! Even just their availability to respond to even the smallest questions... Yes I have good drugstore brands...but THESE 2 PRODUCTS ARE MY LINCHPINS

19 October 2026
Unprompted review
Rated 1 out of 5 stars

Highly unreliable business

Highly unreliable business. All science confirms that the Klotho protein can’t be effectively absorbed topically. This company posts highly questionable science on their website with 10 respondents claiming improvement and no peer reviews. This is a scam. Don’t waste your money!

25 January 2025
Unprompted review
klothoskin.com logo

Reply from klothoskin.com

We wanted you to send our links to our recent IRB approved clinical trials https://journals.lww.com/10.1097/GOX.0000000000008031 This is in the Journal of Plastic and Reconstructive Surgery

https://jddonline.com/a-pilot-study-evaluating-efficacy-of-a-topical-klotho-anti-aging-serum-to-treatable-visible-photoaging/
This was in the Journal of Dermatologic Drugs. This was a double blinded study IRB approved trial.

I also thought you may find our cellular study showing 40% decrease in DNA damage which was done by an independent lab and backed by a NIH grant also of interest https://esmed.org/MRA/mra/article/view/5519

I have also attached the original pilot study that came out in Skin and Aging presented at the American Academy of Cosmetic Surgeons
https://cme.cosmeticsurgery.org/content/utilizing-klotho-protein-and-second-generation-growth-factors-treatment-facial-photo-aging

Further studies can be found on the technology pages on our web site at Klotho Skin.com. We have done 28 years of research on the Klotho gene/protein. Our liposomal technology allows the Klotho protein to penetrate.

We do not ship to the UK so I do not believe you have tried the product. Please reach out to us at info@klothoskin.com if you would like to try it.

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