PlexusDx Reviews 

90
•
TrustScore 4.5 out of 5

4.4

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Review summary

Created with AI, based on recent reviews

Considering 86 reviews, reviewers overwhelmingly had a great experience with this company. Customers frequently praise the fast shipping, seamless delivery, and the incredibly streamlined process for getting started with their medical prescriptions. People consistently note that the support team, care members, and medical staff provide prompt, helpful guidance and clear communication throughout the entire health journey. However, some reviewers were not happy with occasional order errors, delivery delays, or prescription mistakes that required extra time and effort to resolve. A few other people also felt that the initial dosage increases were too slow or experienced frustrating communication gaps with the clinical support team.

What people talk about most

Product

Customers had positive experiences with product, reporting significant weight loss, a noticeable decrease in... See more

Customer service

Reviewers mention positive feedback about customer service, highlighting that support agents and care teams... See more

User experience

Users describe positive interactions with user experience, highlighting how easy it is to navigate the... See more

Service

Clients share positive opinions on service, highlighting quick communication, fast response times, and... See more

Delivery service

Consumers find delivery service to be positive, highlighting extremely quick shipping and reliable... See more

Reviews shaping this summary

Rated 4 out of 5 stars

I am a little frustrated that my prescription was made out to stay on the same dose for 12 weeks so that is why I gave 4 stars. I am really happy with my meeting with a doctor who is hoping to help me... See more

Company replied

Rated 5 out of 5 stars

The team has been so helpful and responsive! I had a great meeting with the medical director, all of my questions were answered. PlexusRX has made me feel supported and excited along this journey! Dow... See more

Company replied

Rated 5 out of 5 stars

My experience with PlexusDx has been really fantastic. Questions answered within minutes and first dose arrived next day. They are really on top of things and J would highly recommend them. I did loo... See more

Company replied

Rated 5 out of 5 stars

What started off a little bit rocky turned into a phenomenal experience. I had placed an order right before a major US holiday causing a shipping Delay. The COO, Adam, MADE SURE to make it right. He p... See more

Company replied


Company details

  1. Fitness and nutrition
  2. also in
  3. Vitamin & Supplements Shop
  4. Wellness Programme

Written by the company

PlexusDx is a science-driven health testing company that empowers individuals to make more informed, personalized health decisions using at-home genetic testing and blood tests. PlexusDx combines DNA analysis and lab-based blood biomarkers to deliver actionable insights across nutrition, metabolism, methylation, hormones, cardiovascular health, inflammation, longevity, and overall wellness. All tests are easy to complete from home and processed by certified laboratories, with results delivered through a secure digital health portal. A core differentiator of PlexusDx is its ability to use a customer’s genetic and blood test results to personalize diet and meal plan recommendations. Rather than generic nutrition advice, PlexusDx analyzes key genetic pathways and blood markers to help guide food choices, dietary patterns, and lifestyle strategies aligned with an individual’s unique biology. PlexusDx also leverages genetic and blood data to provide personalized supplement recommendations, helping customers better understand which nutrients may support their health goals based on their results. These recommendations are designed to complement diet and lifestyle decisions—not replace medical care—and are presented in a clear, easy-to-understand format. PlexusDx is especially known for its advanced Genetic Methylation Test and Methylation Blood Tests, which focus on critical biochemical pathways involved in energy production, detoxification, nutrient metabolism, and cellular function. By pairing genetic methylation insights with blood-based validation, PlexusDx offers a deeper, more complete view of methylation-related health factors. Results are delivered through the PlexusDx Results Portal, where customers can view their reports, personalized insights, and recommendations in one centralized, secure platform. PlexusDx supports HSA and FSA payments and is committed to transparency, data accuracy, and exceptional customer support. Whether you’re seeking personalized nutrition guidance, deeper insight into methylation pathways, or proactive wellness testing, PlexusDx provides trusted, data-driven tools designed to support informed health and lifestyle decisions.


Contact info

4.4

Excellent

TrustScore 4.5 out of 5

90 reviews

5-star
4-star
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1-star

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Replied to 100% of negative reviews

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4.4

All reviews

(90)

90 reviews in the last 12 months

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Rated 5 out of 5 stars

First delivery arrived on time and in…

First delivery arrived on time and in safe styrofoam box to prevent melting. I tried regular dose size a year ago with strong stomach side effects and so far the microdose has not caused any side effects at all.

28 September 2026
Unprompted review
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Reply from PlexusDx

Hey Jane, this is great to hear! Thank you for the review. Your positive review is read by all our employees. - Adam Valentine, COO

Rated 4 out of 5 stars

I've been on a Glp1 for over 2 years…

I've been on a Glp1 for over 2 years and wanted to switch to a compound to decrease cost. I was able to show proof of my current Rx and stay on the same dose. Communication around the dose was a little tricky, so it took about 3 weeks..but it all worked out. Shipping was seemless and fast. I am so happy I have a solution for long term maintenance at a more affordable price.

27 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Lisa! We are always listening. If there is way we can make this a better experience for you, please email support@plexusdx.com. - Adam Valentine, COO

Rated 5 out of 5 stars

Easy process

Easy process, easy intake questionnaire. Medication sent by ups in a refrigerated box. Easy to follow instructions are included, as well as syringes and alcohol prep packets.

7 September 2026
Unprompted review
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Reply from PlexusDx

Thank you for the kind words, Mark. The team works very hard behind the curtain so all our customers can just focus on their health. We read every single review and pass along to the entire team.

- Adam Valentine, COO

Rated 4 out of 5 stars

So far so good

So far so good. Fast approval and delivery. Will come back in a month to see if they are a true 5 star,

16 September 2026
Unprompted review
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Reply from PlexusDx

Moya, thank you for the review. Please let us know about your experience over the next month so we can make sure this 4 star becomes a 5 star. Use your Patient Portal and/or our support box. - Adam Valentine, COO

PS. We read everything, and respond as fast as possible :)

Rated 5 out of 5 stars

My experience with PlexusDx was PERFECT!

PlexusDx is a genuine, reliable provider that truly cares about its clients. My experience could not have been better. Beyond their attention to detail and rapid customer service response, I was approved by a medical practitioner the same day, and my medication was overnighted the following morning.

Having had negative experiences with other compounding pharmacy websites, I thoroughly researched PlexusDx before placing my order. I discovered a legitimate, stable company that is clearly committed to outperforming the competition through a genuine dedication to customer satisfaction. I highly recommend them.

22 September 2026
Unprompted review
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Reply from PlexusDx

David, it was excellent chatting with you and getting your feedback. If you have any issues, you have my direct line! - Adam Valentine, COO

Rated 1 out of 5 stars

Caveat emptor

Last year I went on a regimen of GLP-1, .25 for 4 weeks, .5 for 4 weeks, and 1 for four weeks. I lost 25 lbs. I gained it back, so this year I started again with Plexus. No weight loss at all, in fact I gained weight. The fact that one of the vials was 20 units short is kind of irrelevant. Every now and then I'd email them to tell them what was going on, response was someone would get back to me right away, that went back and forth for 3 weeks before a doctor responded and it really didn't clarify anything. So I'm out >$400 with nothing to show for it. I'd give a zero star if it was available. Now they want me to sign up for another 3 months. Yeah.

21 September 2026
Unprompted review
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Reply from PlexusDx

David, sorry to hear about your experience. We will reach out confirming a full refund.

-Adam Valentine, COO

Rated 5 out of 5 stars

Excellent company, 5 stars!

The entire process with this company was incredibly streamlined. After you answer the personal questionaire *honestly*- a doctor reviews it. For me this was all done within a couple hours. The medication was shipped within hours of me paying. Very fast. Flat fee, no hidden fees. I paid what they said i would pay, no monthly subscription. The communication with the doctor and the customer service have been great, no complaints at all. They communicated all instructions, and I can contact them anytime I need them. I'm super happy I decided to go with this company for my care!!

10 September 2026
Unprompted review
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Reply from PlexusDx

Crystal, thank you for sharing. Your review is an example of a full team effort. I will be sharing this on our Monday team meeting! - Adam Valentine, COO.

Rated 5 out of 5 stars

Great experience

Great experience, the response from the provider was fast, efficient and felt personal when there was some questions about my health history. I received a check-in after starting as well as some great recipe and meal plan ideas which was more than expected and appreciated. So far, the medication has been effective and little side effects.

20 September 2026
Unprompted review
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Reply from PlexusDx

Lorie, experiences like yours are always great to hear. The team puts a lot of work behind the scenes so our customers can just concentrate on their health. -Adam Valentine, COO

Rated 5 out of 5 stars

My experience with PlexusDx has been…

My experience with PlexusDx has been really fantastic. Questions answered within minutes and first dose arrived next day. They are really on top of things and J would highly recommend them. I did look into several other websites but felt really good about PlexusDx and am so happy I went with them! I am doing the micro-dosing and it is super easy to administer.

12 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Jayne! Every employee at PlexusDx sees every review. We are always improving and appreciate every review, and outreach, from our customers. - Adam Valentine, COO

Rated 3 out of 5 stars

It was easy to do the test

It was easy to do the test. Waiting to see how long results take & what results may be.

18 September 2026
Unprompted review
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Reply from PlexusDx

Hey Laurie, we see collected your sample on 9/17. Once our sample is at our lab, the stated turnaround time is 2-4 weeks. Please let us know how we can improve from a 3 star experience - Adam Valentine, COO

Rated 5 out of 5 stars

I applied for a GLP-1 compounded…

I applied for a GLP-1 compounded formula. The approval process took about a day and I received the medication about 5 days later. The prescription arrived expertly cold-packed. I knew exactly when to expect the package as I received consistent delivery notifications. I am currently taking the first 4 week dose schedule. I hope continued refills and increases go as smoothly as the first.

19 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Virginia. Our goal is to do our job so well you don't have to think about us, just your health! - Adam Valentine, COO

Rated 5 out of 5 stars

I had looked for a company…

I had looked for a company approximately 6 months that I trusted. I’m one that always has so many questions and I feel for the customer service employees. I had a small issue, after that I swear every person at PlexusDX was involved. I’ve never seen so many that wanted to help me from Intake, Support and Care. I thank all of you for sensing my fear if I was doing the right thing . You were patient and kind. Everything turned out great. I received my order today and the wonderful nurses walked me through the injection. Thank you to the delivery service and packing because the product was on ice and neatly organized and really if I hadn’t called the nurse I probably could have done it myself. But I just wanted to make sure I was doing everything right. Also thank you Adam Valentine for making this possible. I will recommend you all. I’ll be in touch. Thank you again.

11 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Debbie! Every review is a team effort. I am always happy to pass a review along to the team on a Friday night. - Adam Valentine, COO

Rated 5 out of 5 stars

I’m giving a 5 star but I really…

I’m giving a 5 star but I really haven’t done this long enough to know any different. Shipping wasn’t very fast for me. UPS is not the best. For 2 days they said my medication was due to arrive and it didn’t. I finally got my prescription and I just wish they didn’t take so long arriving. It’s probably a UPS thing though. As far as meds, I’m on my 2nd week and giving it a chance.

10 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Stefanie, this is great feedback. I will make sure the team knows. - Adam Valentine, COO

Rated 4 out of 5 stars

Quick and easy

So far PLexusDX was easy to join, with no hidden fees, fast and linear process to get to the first dose. Communication was straightfarward, nothing to complain.

6 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Jessica! We appreciate, and read, every review. Have a great weekend. -Adam Valentine COO

Rated 5 out of 5 stars

Fantastic experience & support

Everything from the beginning has made a lasting impression. From the personal text messages with very thorough, kind and respectful responses to processing what would fit best for our needs, including amazing support from the care team(s). I am continuing my journey with PlexusDX and look forward to future support and options. No harassing calls or emails like other brands we have researched and I truly appreciate that.

7 July 2026
Unprompted review
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Reply from PlexusDx

Lindsey, thank you for the kind words. Every review is a team effort. Everyone in the company reads every review. - Adam Valentine, COO

Rated 1 out of 5 stars

If I could give this company a -100…

If I could give this company a -100 stars, I would. What started as a great experience has turned into a bit of a nightmare. When I initially ordered, I thoroughly read the information on the PlexusDx site. There is no mention that there’s additives in the tirzepatide medication. I believed based on the company's website that I was getting pure tirzepatide.
When I got the prescription sent over from the provider, I immediately reached out and told PlexusDx that I cannot have any additives in the medication due to a previous severe allergic reaction and asked that the pharmacy not fill that prescription. I also asked where the additive information was located on the company’s website because I looked all over it before placing my order and could not find anything. No one from PlexusDx could tell me where that information was disclosed - because it’s not. The company then shipped me the medication - despite my request not to fill - with the additive I had told them I am severely allergic to.
I requested a refund on August 27 after trying to work with PlexusDx for several weeks. I was told multiple times that my refund request was “with the billing team”.
On September 14, I got a notice that a prescription was written filled and shipped - 18 days after I canceled and requested a refund. To reiterate, from 8/27 forward, I reached out multiple times about my request for a refund and every single time got the response that it was with the billing team. I never heard from the billing team.
You can imagine my shock when 18 days later, with no response to my requests for a refund, PlexusDx filled and shipped more medication.
My credit card company is now fighting with this company to get them to refund my money.
Today I got ANOTHER NOTIFICATION that PlexusDx had sent out more medication, which is pretty unbelievable since they just shipped me medication 2 days ago - instead of giving me a refund.
It’s like Groundhog Day with this company. I canceled and requested a refund 21 days ago. Seriously quit sending me meds and just refund my money.

27 August 2026
Unprompted review
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Reply from PlexusDx

Shauna, I reviewed your interactions and we clearly failed you.

1. I will personally oversee the refund (that is happening now)
2. As a cancer survivor, I got into this business to help people. Your experience was subpar and changes will be made internally.
3. We offer compounded tirzepatide, and I see you specifically requested tirzepatide with an additive, that will be on your doorstep tomorrow. You can keep it. Your refund will still go through.

I expect confirmation of your refund, shortly. - Adam Valentine, COO

Rated 5 out of 5 stars

Very helpful chat

Very helpful chat. The care team answered all my questions very quickly. The whole process was very efficient and easy.

14 September 2026
Unprompted review
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Reply from PlexusDx

Thank you for the review, Randi! Any review we get team effort. - Adam Valentine, COO

Rated 5 out of 5 stars

I've been working with PlexusDx for the…

I've been working with PlexusDx for the last 2 months and it has been a great experience. Customer service and doctor communication has been excellent. All my questions have been answered quickly. Prescriptions are filled fast and shipped 2nd day air. I'm very pleased and plan to continue working with PlexusDx.

9 September 2026
Unprompted review
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Reply from PlexusDx

Thank you Sarah! I will pass along your review to the team. Every review is a team effort over here. - Adam Valentine, COO

Rated 5 out of 5 stars

So far its been a great experience

So far its been a great experience! Got approved for treatment in less than 5 hours, then shipped and arrived in less than 3 days. No side effects so far. Hoping refills go smoothly. Excited for this journey!

31 August 2026
Unprompted review
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Reply from PlexusDx

Thank you Jamie! I just posted this review to our internal Slack. Kind words like these at the end of a long day are extra special. Thank you (again). -Adam Valentine, COO

Rated 5 out of 5 stars

Worthwhile

Initially there was some confusion in regards to my dosage, but that was resolved and no further issues.

4 August 2026
Unprompted review
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Reply from PlexusDx

We are glad we could get everything sorted out. We got in this business to help people. - Adam Valentine, COO

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