Samphire Neuroscience Reviews 

Being in the US, I had to run out and buy a EU to US plug adapter to charge it, but it was so worth it!!! On my first cycle using it, my PMDD was greatly reduced, but I realized I could probably benefit from using it a little longer than I did. For my second cycle I started using it earlier in the month, and will keep using it a couple days longer than I did before. It can take a little while to find your ideal number and timing of sessions, but it’s easy enough to use and I love the results I’m getting from Nettle so far. Also, the stimulation from it is much milder than I expected, to the point I actually felt a little silly in hindsight, but that’s great because it’s not uncomfortable or distracting if you’re doing other things while using it.

I'm really torn over how to rate this, as I love the company, their research, and Emile the founder is amazing in both her knowledge & customer service. However, ultimately I bought the product to treat my PMDD, and sadly it didn’t work for me. I do seem to be in the minority - I’m quite jealous of all these “life changing” reviews, as SO wanted it to work, but it just didn’t.

I admit I’m not a black-and-white case, so perhaps I’m the problem, not Nettle; I have PMDD, I’m perimenopausal, plus my cycles are irregular and I’m not sure I’m even ovulating having come off birth control - Emile was very helpful in advising how to use Nettle with PMDD / an irregular cycle & I ended up using it every day except whilst I was on my period.

As I said, I really really wanted it to work, I can see the research & science is there, but for me, unfortunately there was no improvement in my PMDD symptoms for the three months that I used Nettle.

Despite this, I really would urge anyone to give it a go, so long as the 90-day returns policy is in place, because if you suffer from this hideous condition, surely it’s worth a try??

Really loving this product and company! They reply fast to questions and concerns and try their best to help you.

As for the Nettle I've used it for 3 cycles and it's helped me with my symptoms greatly. It's easy and feels safe to set up and I actually look forward to using it every month.

You can try it free for 90 days and return it if it didn't fit you but I will definitely keep mine!

I've only had the nettle for two cycles so far and one started so early I missed the chance to use nettle, it seems like the app will help get better predictions for when the cycle will start.

I have noticed feeling calmer and less pain, which I'm very grateful for

Checking back in after 6 months, my pain and mood symptoms are definitely reduced to a manageable level. I'll be using nettle for the long run and I'm very glad I bought it

I have PMDD and when I first heard of Nettle via the instagram algorithm, I was super skeptical because I did not want to get my hopes up as I’d done many times before with various treatments which always failed to help my PMDD and which often came with a ton of side effects. However, after a particularly bad month I finally decided to take the plunge and try Nettle, since I knew I could return it for a full refund if I didn’t feel a difference after three months. The first month went by and I didn’t feel a lot of change, I wanted it to work but I was super skeptical that it would. By the second month I noticed amazing improvement in most of my symptoms. I no longer had severe mood swings, I did not have severe cramps or fatigue, bloating was visibly reduced, my relationship with my partner improved vastly, and I even used Nettle when I felt an incoming migraine and it stopped it in its tracks. The only thing the Nettle didn’t help me with was insomnia (but this could be from general stress rather than hormones). I really cannot sing the praises of this device enough and urge every woman out there who is suffering to give it a try! The Samphire website gives all the information about clinical trials for Nettle as well as tons of content about female health and research in general, a topic I am very passionate about. Since it’s a start up, the CEO and founder, Em, is very hands on, and checks in with new users regularly to listen to their experience and answer any questions they may have. You can even schedule a video call with her in person! As a scientist myself, it’s so amazing to see research translated into practical tools helping women! The world needs more companies like Samphire, and I cannot thank Em and team enough for giving me back a quality of life I thought I’d lost forever!

I've been using the device since November 2024. The device is worth every cent. I had problems with the first device, but I wrote to Em and received all the support I needed, as well as a new device. Fantastic service and the wonderful Em. THANK YOU.

But the most important thing is that it works, the PMS symptoms and pain have decreased, I feel relief and endless gratitude that finally someone paid attention to women and their problems. I'm so proud of you, Em, you did it!

Nettle has been life-changing for me. It has significantly improved my mental health, not just during the intense phases of PMDD before my period. But I actually feel much better during the rest of my cycle, too. The improvement of my pain has been slower and has little effect in my case so far, but I don’t mind that, considering how well it works for my mood. Samphire has been truly brilliant in supporting me with questions I've had and also have been very generous when it came to technical issues. The founder Emilie is very accessible, and makes time for you. I am routing for Samphire Nettle and hope that many women will benefit from it - I certainly tell everyone about it.

This is a pioneering new product and I have found it life changing.
I have complete faith in the company as their customer service has been impeccable. I can't thank them or recommend them highly enough.

I've been using Nettle for 4 months so far, and I can see my body adjusting and feeling symptoms relieved.

The first time I received Nettle was during my period, so I ended up with 4 sessions till the end of the period. Then the second time I had 8 sessions before my period and a few more during the first few days of the period. This time my usually severe premenstrual breast tenderness was almost non-existent! During the period, I still needed painkillers, though 2 pills less than usual, and that was already a win!

The third time, I had around 12 sessions before my period and 3 more during the first 3 days. And instead of the usual 5-6 strong ibuprofen pills during the first 3 days, this time I needed just one! Yes, I still felt very weak but not as exhausted as usual when I'm on my period. The pain was present, but nothing to compare to what I'm used to experiencing. However, the premenstrual breast tenderness came back almost as severe as earlier.

The 4th and 5th time, I experimented by using Nettle about 20 times (as advised by Emilė) before my period. However, my body doesn't seem to respond right away to this boost. The breast tenderness hasn't changed, and the period pain is still pretty significant (2 strong ibuprofen pills were needed both times), as well as exhaustion before the start and during the first few days of the cycle.

But I am hopeful that this is just a question of time since only 2 instead of 5 or 6 ibuprofen pills is already an incredible win for me!

HUGE thanks to Em and the team for all the support!

Great device you can take care of yourself at home. A luxary now when you see how the care systems goes worth and worth

The Nettle has genuinely changed my life. I hope that anyone considering this for PMDD or PMS invests in themselves by buying this device and giving it a go. I spent so much money on other options that didn't work. I would spend this money many times over for the relief it has given me.

I have PMDD and I tried all the suggested options from my GP/online and none of them have provided any relief of my symptoms. I bought the Nettle in Dec 24 and tried it for two cycles but had no change.

I had an email from the company which gave me the opportunity to speak to Em the CEO. I wanted to give the device another chance and we discussed my personal circumstances and how to make it work for me.

The third cycle of trying it, it made a huge impact on my symptoms and I would say reduced them by around 50%. I could start to see through the fog and I was able to work, when usually I would be impacted so much that I would take between 1 and 3 days off to manage my symptoms.

I have just finished my fourth cycle of trying it and my symptoms were reduced to about 10%. It felt like very mild PMS compared to the severe, life threatening PMDD I usually suffer with. I hope I continue to have great results.

This device has given me my life back and I can't thank Em and the team enough. I would love to know if there is a way that this could be offered as the first line treatment by GPs. This should be offered ahead of birth control or antidepressants, as there are no side effects to using the device (in my experience).

If you're reading this wondering if you should try it...you should.

Incredible - Nettle has helped me immensely and the customer service is also brilliant. I have PMDD and ADHD which I don’t medicate for and I was surprised/delighted that it significantly reduced the symptoms of both of these conditions. Over the course of a few months, my brain has felt clearer and less chaotic - a huge factor when considering these conditions are largely neurological as opposed to physical (although nettle does massively reduce my period pain too). I also love that they value and actually take on board any feedback, showing they actually care about being the best possible vessel for period sufferers.

Very grateful for Nettle. Thank you to these women for being so dedicated to helping other women.

The Nettle device changed everything, I bought this device before Christmas and experienced the festive season in a much happier more level mood! This little device has helped me in so many ways, I feel like a different person during luteal, no extreme anxiety or depression, my partner has commented that it has made a visible change in my symptoms. The app is brilliant too, lots of free useful resources etc. It feels like a little luxury to use and gives me a boost when I need it, I actually time mine for the afternoon if I can as that's when I tend to "crash" energy wise. Try it out, you have nothing to lose :)

To make this review as helpful as possible for people considering purchasing Nettle, I’ll start with some context.
- Ever since I first got my period, I struggled with PMS. Every month without fail my mood would change and my mum would ask me “are you due on?” And 9 times out of 10, I was.

- In my late teens I became very unwell with depression and have been on antidepressants ever since. Despite being on medication, my PMS has stayed with me over the last 10 years. In the 8-10 days before my period, I am not myself and my day to day life and routine is negatively impacted.

- When I have tried to come off my medication (which I now realise isn’t an option for me), my PMS would get significantly worse and I’m pretty sure I actually have PMDD (though I’ve never been diagnosed).

- As I’ve been conscious of how artificial hormones could impact my mood, I’ve never been on hormonal contraception but have had the copper coil which makes my periods painful and heavy. I go through a pack of Feminax every month without fail.

That’s some context about me and now about my experience with Nettle…

I’m now mid way through my second time using Nettle and I start using it 8 days before my period is due.

The first time I used it, I had one bad pms day which was on the 3rd day of using Nettle and bar that, my mood remained unchanged and therefore so did my sleep, my ability to maintain my exercise routine, energy levels, diet etc. To my amazement, I also had ZERO pain. I was expecting to have some pain but not enough to warrant painkillers but I had NOTHING.

I am now using Nettle for the second time (am on day 3 of usage) and again, am finding it game changing for managing my PMS. )

I wish I could put into words how grateful I am to Em for creating this incredible piece of technology. If you feel like you’ve tried everything to manage your PMS/PMDD and/or pain to no avail, I can’t recommend Nettle enough.

I have no doubt this is going to change the lives of millions of women - it has definitely changed mine already.

Thank you again Em!

I have always experienced challenging PMS symptoms however I noticed these worsen in the past year to two years and become more akin to PMDD with heightened period pain. My symptoms start after ovulation up to the first few days of my period and I was finding that this was becoming more unmanageable impacting daily life and activities, especially the low mood and anxiousness, wipe out fatigue and feelings of agitation and hopelessness during the luteal phase.

I’m really pleased I found Nettle, and I took the leap and made the purchase. I’ve been using now for three months, and I’ve been using daily from ovulation up to day 2 or 3 of my period. I have had fewer fatigue and low mood and emotional spells during the luteal phase, being able to pick myself up quicker after these and returning to a calmer mental state. I’ve noticed that this month my period arrived without the usual cramping as signal of arrival. I have had day 1 period pains only as these usually stay till day 3, which is a big improvement!

The device and app are both easy to use. I enjoy the 20 minutes of time to myself whilst in session. The tingling took a few sessions to get used to but now find the sensation comfortable. Em and the team are so supportive, especially when I needed help with my device set-up.

I am positive my symptoms will continue to lessen with every month I use the Nettle. It’s nice to have hopefulness about my cycle after all this time and am very grateful to team Nettle.

 

I waited several months after buying my Nettle to write this review so I could give an informed opinion. After three full menstrual cycles with it, here’s my take.

Does it work? Yes.
Does it need improvement? Yes.
Will it be improved? I believe so.
Should you buy it? If you have PMDD, yes. This is an essential investment that you need in your life.

Pros:
- Outperforms all other PMDD solutions I’ve tried (and I’ve tried them all).
- Customer service is stellar.
- Company clearly cares about delivering results and improving user experience.

Cons:
- A pain to use (but results are worth it).
- Some devices may malfunction (but customer service is excellent, and as long as they continue to be this responsive I can feel comfortable recommending the product).
- First-gen product, so it’s not perfect—hopefully, there will be a trade-in program in the future for early adopters to upgrade to improved versions. I won't lie, it does give me anxiety to feel unsure if my device will work or not when I come to use it, especially since I travel often.

My Experience:
I have PMDD (Premenstrual Dysphoric Disorder), which is like PMS on steroids. I was diagnosed at 24 and have spent over a decade trying to manage symptoms that take half my life away. The worst part is the depression and brain fog—I struggle to form sentences, misplace objects in bizarre places, and even accidentally drank a cleaning product once.

I’ve been prescribed antidepressants, Elvanse, birth control, and was even suggested HRT. Nothing worked, and side effects were awful. When I saw an ad for Nettle’s neurostimulation approach, I was hopeful.

First cycle: Noticeable mood improvements by Day 3.

Second cycle: Started using it earlier—huge relief from PMDD depression and anxiety.

Third cycle: Used it twice daily in the 14-day lead-up and was shocked—I was in control of my life. PMDD’s usual slow-motion train wreck just didn’t happen. Instead of struggling to function, I could think, work, and live normally.

For pain management, I expected nothing, and nothing happened for my first cycle. Usual excruciating pain. But by my third cycle, I had just three hours of cramps on day 1. No painkillers needed. Unbelievable.

Customer Service:
Excellent. My first two devices stopped working. In both cases, replacements were sent quickly. The first time, the CEO herself replied within something like an hour—on a Saturday night. She's even followed up with personalized advice to my many questions. Probably not something that she can keep doing as the company grows, but her level of commitment is absolutely palpable and I'm impressed.

The Downsides:
Using Nettle is frustrating. The marketing doesn’t prepare you for just how much water you may need to wet the electrodes. I need to soak them with at least ½ to ⅔ of the provided bottle each session. Even then, I have to press, rock, remove, and re-wet for at least 3 rounds before the device connects. The water also drips everywhere, which may explain why some devices malfunction.

For context, I have type 1A hair (straight, low porosity, thick strands); you may have an easier time with fine hair. Washing my hair daily made no difference, so it's not oil buildup.

Essentially, ignore the website's marketing images that imply an easy pop-on-pop-off device. Your hair will not look sleek and groomed when you use this. It will be necessary for you to take time out of your day to look ridiculous. I’ve resorted to a 2 ponytail arrangement (one mini to pull through the gap, one to separate back and half) to maximise scalp contact. I also have to blow-dry my hair post-session. But, the fact that I recommend this product despite all the frustration says everything about how much the results deliver.

Final Verdict:
Despite the frustrating user experience, Nettle is a game-changer for PMDD. It’s not perfect, but it delivers results. If you struggle with PMDD, Nettle is the solution you’ve been waiting for. Absolutely worth the investment. I just hope they continue improving it!

Using the Nettle has absolutely blown my mind (haha, not literally). My luteal phase, is no longer a week filled with heightened emotions like anxiety and anger. I feel like the Nettle clicks on the happy side of my brain, in the phase of my cycle that I need it the most. It's an absolute game changer. Also the customer support service is incredible, so friendly and so responsive! Thank you Samphire Neuroscience, for changing how women navigate the highs and lows of the beautiful but complex menstrual cycle.

I've used nettle for one month and so far so good! I definitely noticed an improvement in my mood and PMS symptoms and I didn't need any painkillers during my period this time. I have thick curly hair and found that I needed to part my hair in a certain way so that contact was detected and sessions could start - Em was very helpful, providing advice so I could get it to work. Your hair does get wet so have the hairdryer ready for a quick touch up!

I am very happy with Nettle! At first I had some doubts, but after the first cycles of use I noticed positive changes. It is easy to integrate into my daily routine and the effects are really noticeable - I feel more energetic and focused. I also really appreciate the support of the community and the care of the team. Thank you for creating such innovative solutions!

Absolutely love it, with second cycle significantly reduced PMS symptoms, I feel much more mentally stable and calm.
Thank you!