Samphire Neuroscience Reviews 

I’ve waiting for 2 months before writing this review to make sure I have enough experience with the app and the device. I have quite lengthy and severe premenstrual symptoms which ramped up just before I turned 40. My GP suggested for me to consult with a menopausal specialist nurse. The nurse suggested that I keep record of my symptoms for 3 months and can see that I have something everyday but more so 10-12 days before my period. She suspected I have PMDD. However, on my 3rd month check, I’ve turned 40, the diagnosis then turned to premenopausal and was suggested HRT. Since I was really struggling with severe migraines, irritability, anxiety, cramps, muscle aches weeks before my period, I gave HRT a try. Initially I felt really great, symptoms almost all gone - except when I had the progesterone, all hell broke loose. I noticed after 1,5months, I gained weight without any change of exercise or calorie intake. I worked hard to maintain my health and my body and for some reason I swell. I decided to stop HRT and at the same time found Nettle by coincidence.

Nettle is on the pricey side, however I had nothing to lose. It’s not hormonal, so won’t change my body, that’s good enough. When it arrived, it didn’t really fit me, so I emailed for some guidance. Emily (bless her), she’s so patient with me, guided me through it and it worked wonders. I also explained my situation and that I start feeling symptoms way before the ‘5 day before period starts’. She then suggested for me to do it as soon as my symptoms start. I now have it scheduled 12 days before my period. I only use them when I can’t handle my symptoms.

If I wake up with a migraine/cramps or start to feel anxious/low mood, I get my nettle and it sorts me back to neutral (like a factory reset lol) after 20 mins. I also use this 20 mins as my ‘me quiet time’.

It’s been such a dream to have nettle, thank you Emily for creating such a miracle. I’m so much less moody, no where near as irritable or anxious as I was before, I can bring myself up to go for a run when at times I don’t feel like it, my migraines are almost second to none, I barely take pain killers, even my husband borrows my nettle when he has migraines haha.

Now, the app compliments this device. I can’t praise it more than what the device has helped me. The app is so customizable and it has everything that I need that no other app has managed to provide. You can add your own symptoms, select the level of severity and even have analytics of each symptoms.

If you struggle with PMS/PMDD or any sort of menstrual related pain/emotional struggle, give nettle a go.

I hope you find solace like I do.

If you have a Nettle device from Samphire neuroscience and did not receive significant relief during your first cycle, I highly recommend giving it another try in the second cycle. The instructions note that it can take up to three cycles to see significant reduction in symptoms, and that is the case for me. I found a decent amount of relief during the first month I tried this device, and am seeing an incredible improvement in the second month. There is still some head tingling and discomfort, but I now look forward to the feeling, knowing that it will help me feel clear-headed, calm, and in minimal pain even if it’s “that time of the month.” I started using it a few days before PMDD symptoms usually set in, and this has worked incredibly well so far. To my fellow PMDD sufferers: hope has arrived.

I was diagnosed with endometriosis last summer after years of debilitating ovulation pain. I had always had bad mittelschmerz but in 2024 it became far more severe, to the extent that I was hospitalised twice, and the pain was so severe that during ovulation I would be incapacitated for 7-10 days. No painkillers did anything other than worsen my GORD. I saw a gynaecologist who suggested either going on the pill (which caused terrible mental health problems in the past and also I am happy with my Mirena IUD), induced menopause, or a hysterectomy. None of which seemed like good options! I went away and did a lot of research, and decided to take the leap with Nettle and I am SO glad I did.

I fit my Nettle schedule around meditation, which is quite simpatico. It does tingle a little, but overall it's really easy to use and I don't really notice it.

My first cycle using it was just after ovulation, and the first and most immediate side effect was a mood shift. My irritability and brain fog were much quieter. The second cycle was the real test as it was my right ovary (I think she wants to kill me) and causes significantly more pain than the left. I definitely still felt pain, but it lasted a few hours instead of ten days, and I was still able to do things — albeit with a hot water bottle strapped onto me. I'm hopeful that by the next right ovary cycle, the pain will be even less.

The biggest shift in the second month was my lifelong depression just sort of vanishing?? The hormonal despair that has dominated my life since menarche has just gone, I feel stable and not overwhelmed. Finding Nettle really has been a game changer, and I am excited for what feels like the very near future where my body and life isn't being dominated by pain. Thank you!

I'm currently using Nettle for the second month and, so far, I'm very positive about my experience. I got it to relieve (mental) PMS symptoms and, even during the first cycle of using, the symptoms were significantly less. I feel better - less depressed, less tired, and less sad.

The device is costly, but worth the money to me!

Update after the 2nd use cycle: my period was about 2 weeks late. This was scary, and since I wasn't pregnant, I emailed the Nettle team if it could possibly be a side effect. Emily responded within the hour, and it can indeed be a side effect of the device. It's supposed to go back to normal with the next cycle. I really appreciated the quick help from Emily, and the reassurance that there was nothing to worry about. I'm about to get my next period, so let's see if this one will be on time!

This is my first month using Nettle, and I can't believe how fast it worked! As my period was approaching, I was waiting for my usual PMS/PMDD feelings of depression, sadness, and irritability to hit me - but I started stimulating my brain with Nettle and those never came! I am SHOCKED that it worked so fast. I feel happy, calm, and productive. As someone with PMDD, I don't think I ever felt this good before my period. Turns out, "it was all in my brain"!

Also, as someone very passionate about good design, whoever designed Nettle, did a good job. My daily Nettle sessions feel like a luxurious ritual. It's also super easy to use and I even like the slight tingling sensation I get when stimulating my brain.

It only takes 20 minutes, and you can do whatever you want during those 20 minutes: work, reply to emails, watch Netflix, relax, etc. It also gave me a little sense of achievement every time I finished a session - and it had this ripple positive effect on my day, where I would want to do more self-care, drink more water, etc., because I already started it on a good note with Nettle.

I seriously cannot recommend this enough, and I want all my friends to know about Nettle!

I wanted to share my experience with the Nettle headband as someone with complex health conditions, hoping it helps others considering this treatment.
The most remarkable effect came on day one: I experienced temporary sensation in areas affected by hemiplegia for the past decade. Specifically, I could feel texture and temperature on the right side of my face during the session and for about 20 minutes after - something I hadn't experienced in 10 years. While the full sensation didn't persist, it was amazing.
Regarding menstrual symptoms, which were previously severe (requiring strong pain medication and causing severe nausea/vomiting): my first period after starting Nettle was notably different. The pain was minimal - describable as "distant" rather than overwhelming. I only needed occasional CBD and a hot water bottle, rather than my usual medications. The bleeding pattern also changed, becoming lighter and more manageable.
I did experience one day of prolonged scalp irritation sensation (without visible inflammation) and a light headache, but these resolved within 24 hours. Subsequent sessions were more comfortable.

The Nettle from Samphire Neuroscience is absolutely a game-changing breakthrough in the field of female health. I have suffered from debilitating PMDD for the past 3 years and have noticed a significant improvement in my mood since using the Nettle. No other treatments have delivered on their promises like the Nettle has, and no other treatments are targeting the root of the problem like the Nettle does. The app experience is seamless. The customer service and support is INCREDIBLE. The product itself is comfortable and easy to use. I experienced a tiny tingling when I first started using the Nettle, but I've since gotten very used to it - and now I can't wait to stimulate when I get home. Thank goodness for this product and the breakthrough work they are doing at Samphire Neuro. Keep up the great work!! I highly recommend.

I've been using the Nettle for three months, and the changes have been remarkable. My mood and motivation have improved significantly, and I’ve experienced zero menstrual pain! it’s been a total game-changer! I’m honestly blown away by this incredible technology and wish more women could experience its benefits.

I've been having period pain since I was 12, started having or realized having strong anxiety symptoms and depressions (low motivation, strong fatigue, irritability, low mood) on a cycled schedule from day 19 to day 26 of my cycle. Like a clock.
Realized that and tried to work on it with very good habits (exercises, routines, diet), mental health support and treatment, I have a very nice supportive partner. I tried taking more vitamins B spectrum, calcium, zinc, magnesium, omega 3 throughout my cycle. I took melatonin to sleep, implemented a sleep routine, etc. Honestly, tried it all. It all helped to a certain degree, but theses days (19 to 26) were still bad mood day, just good behavior and doing what I had to do. I tried the Nettle on day 21 to 25 since that's when I received it. Wow, one of my most annoying symptoms was insomnia, I couldn't fall asleep on most of theses days.
I just felt sleepy at 22h00 and fell asleep that night. Day 21 is usually more about anxious feeling, overwhelmed in general, lil hamster racing. Well. After the nettle my mood was normal like in my follicular phase. The day after, I was doing great, like my normal me. I feel deeply lucky and grateful. My partner notice how much more productive and cheery I am for this phase of my cycle. For me the fact that I fell asleep so easily is truly a signs that it works. Emotions are sometime's complex to isolate but sleeping? I didn't even think of having this great outcome. I would sincerely suggest to try it. I will keep updating in the next months for the period pain and if the improvement are stable.

Also for the side effect: all I have is some itchiness during the treatment. I would say I'm sensitive to feel things, but tolerate well strong sensation. This is light and I don't see how it could discourage anyone to continue treatment since it's helping me with my mood, mindfullness and sleeping habit therefore also my productivity and stress level. :)
I didn't get any headaches, nausea or tingling as mentionned in the description of possible side effects.

It's also very easy to install since the video show all the steps for it and it's quit simple.
20 mins of chatting with my partner or cuddling with the cats usually during.

Worth my money cause damn I spent so much more on trying all the other stuff that didn't help as much as this.

I came across Nettle a bit in despair for a solution for a) heavily noticeable PMS symptoms that affected my life before and during my period and b) very strong period cramps and high pain levels. To this date I had not found a solution for any of the PMS symptoms and the only solution I found to treat the pain was general painkillers. The pain is so strong that I start taking them 2 days before my period and continue back to back until pretty much the period ends. Even with that, the pain is normally not fully gone.

I am a very recent user of Nettle and lucky for me, it came just in time to try it out 5 days before my last period. During the 5-6 first sessions, I could notice straight away changes in my mood. My head was clear and it felt I was in the right mindset to get going with normal tasks during my day (work, exercise, social events, etc..). Regarding pain, I still experienced strong cramps in days 2 and 3 of the period and I had to resort to painkillers during those days; however, the amount of painkillers I needed to take decreased significantly from around 9 days (before and during period) to just only 2 (during period).

Using the device is very straightforward. Personally, I need to add lots of water to the sponges to have good contact but after some sessions it is easy to figure out what works for you.

I am looking forward to trying it more consistently in upcoming cycles!

I am absolutely amazed by Nettle! After just seven sessions, I’ve noticed a remarkable positive effect, especially emotionally. Normally, I struggle with depression, self-doubt, and a significant lack of energy right before my period—but this time, none of that! Instead, I feel empowered, confident, and full of energy. Even my period itself was less painful; for the first time, I didn’t need painkillers (and I usually rely on 2-3 ibuprofen). The pain was manageable, and that alone is a huge relief.
My therapist also noticed that I seemed much more stable and balanced.
The application process is super easy: during use, there’s a tingling sensation on the scalp, which felt a bit strange at first but quickly became ok—especially when adjusting the device to fit better. The app is intuitive and guides you seamlessly through the process, with clear and simple instructions. The customer support is warm and responsive; every question I had was answered promptly.

To me, this feels like the future of PMDD treatment—revolutionary! For the first time in years, I feel like I’ve regained a sense of control over my life as someone who suffers from PMDD. Although it’s still early, and I’m only one cycle in, I’m already so grateful to have found Nettle. This is an honest, unpaid review from a deeply satisfied user. I’m looking forward to sharing more updates if anything changes. Highly recommended for anyone dealing with PMDD!

I was skeptical at first, unsure if the headband would help me. It does! My mood swings have significantly decreased and so has my cramps. The band can take a little getting used to, but it’s so worth it. It took a few months (about 3 months) of proper use before I actually started seeing the effect but I expected that.

I’ve been using the Nettle headband by Samphire Neuroscience almost since it’s launch and it’s made a remarkable difference to my depression and anxiety that I experience as a result of PMDD. I have a long cycle and experience 2 weeks of PMDD that used to feel completely unmanageable, when I use Nettle from ovulation onwards I experience a significant reduction in symptoms. I’ve also tried other treatments including antidepressants and TMS but none have been as effective in alleviating some of my symptoms. It’s also great to be able to use it at home and to not have to commute anywhere or have any extra appointments. The app is very informative and the team are lovely and respond quickly to any questions or concerns. I’d highly recommend trying it if you have the opportunity!

I have been using Nettle for almost a year and it is truly a life-changing creation (if you are a woman suffering from PMS of course). It has not only helped me to become more aware and be more in tune with my body, but made me more conscious about my bodily sensitivity. The headband has a tingling sensation and the interesting part is that the sensation varies in intensity of sensation (even though the strength of stimulation does not change) depending on the day of the cycle. It's fascinating how our bodies work and I hate to think I used to heavily fill it with painkillers every month.